GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| BRCA | cis | rs703842 | 1 | rs10431505 | chr12:58178589 | B4GALNT1 | chr12:58019551-58026985:- | 0.12 | 3.6 | 0.00033 | Multiple sclerosis |
| BRCA | cis | rs703842 | 1 | rs10431505 | chr12:58178589 | FAM119B | chr12:58166383-58176323:+ | 0.43 | 11.02 | 8.37E-27 | Multiple sclerosis |
| BRCA | cis | rs703842 | 1 | rs10431505 | chr12:58178589 | TSFM | chr12:58176536-58191367:+ | -0.34 | -10.38 | 4.1E-24 | Multiple sclerosis |
| BRCA | cis | rs703842 | 1 | rs10431505 | chr12:58178589 | XRCC6BP1 | chr12:58335445-58351051:+ | -0.18 | -5.03 | 5.7E-7 | Multiple sclerosis |
| BRCA | cis | rs4803468 | 1 | rs1043413 | chr19:41939297 | B3GNT8 | chr19:41931265-41934635:- | 0.21 | 6.3 | 4.26E-10 | Height |
| BRCA | cis | rs2076028 | 1 | rs1043441 | chr22:39130964 | APOBEC3C | chr22:39410265-39414823:+ | -0.11 | -4.08 | 4.81E-5 | Resting heart rate |
| BRCA | cis | rs2076028 | 1 | rs1043441 | chr22:39130964 | JOSD1 | chr22:39081549-39096459:- | -0.14 | -4.2 | 2.9E-5 | Resting heart rate |
| BRCA | cis | rs2076028 | 1 | rs1043441 | chr22:39130964 | LOC646851 | chr22:38974125-39052634:- | 0.13 | 3.65 | 0.000279 | Resting heart rate |
| BRCA | cis | rs2076028 | 1 | rs1043441 | chr22:39130964 | TOMM22 | chr22:39077954-39080763:+ | -0.11 | -3.41 | 0.000665 | Resting heart rate |
| BRCA | cis | rs1799922 | 1 | rs1043550 | chr7:128409225 | OPN1SW | chr7:128412545-128415844:- | 0.16 | 3.91 | 9.69E-5 | Primary tooth development (time to first tooth eruption);Primary tooth development (number of teeth) |
| BRCA | cis | rs6087771 | 1 | rs10439608 | chr20:30258814 | COX4I2 | chr20:30225691-30232800:+ | 0.18 | 6.81 | 1.59E-11 | Subcortical brain region volumes |
| BRCA | cis | rs6087771 | 1 | rs10439608 | chr20:30258814 | MYLK2 | chr20:30407178-30422500:+ | 0.31 | 7.98 | 3.88E-15 | Subcortical brain region volumes |
| BRCA | cis | rs6690583 | 1 | rs10443172 | chr1:85485768 | MCOLN2 | chr1:85391267-85462796:- | 0.16 | 4.64 | 3.94E-6 | Serum sulfate level |
| BRCA | cis | rs10444533 | 1 | rs10444533 | chr12:107229705 | C12orf23 | chr12:107349544-107367811:+ | 0.17 | 4.1 | 4.4E-5 | Social autistic-like traits |
| BRCA | cis | rs10444533 | 1 | rs10444533 | chr12:107229705 | MTERFD3 | chr12:107371069-107380929:- | 0.17 | 4.89 | 1.18E-6 | Social autistic-like traits |